SUCCINATE DEHYDROGENASE DEFICIENCY-DRIVEN SUCCINATE ACCUMULATION INDUCES DRUG RESISTANCE IN ACUTE MYELOID LEUKEMIA VIA UBIQUITIN-CULLIN REGULATION

Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation

Abstract Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism Accessories remains poorly understood.Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct metabolic processes.Here, we identify succinate dehydrogenase (SDH) def

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Development of a complex intervention to improve participation of nursing home residents with joint contractures: a mixed-method study

Abstract Background Joint contractures in nursing home residents limit the capacity to perform daily activities and restrict social participation.The purpose of this study was to develop 12VDC Cigarette Socket Gear a complex intervention to improve participation in nursing home residents with joint contractures.Methods The development followed the

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Arthropod-based biotic integrity indices: A novel tool for evaluating the ecological condition of native forests in the Azores archipelago

Island ecosystems are experiencing a significant decline in biodiversity, with forest biodiversity being particularly affected by several biodiversity erosion drivers.This alarming situation highlights the urgent need for conservation managers to Hotpoint HUE61PS 60cm Wide Double Oven Electric Cooker With Ceramic Hob develop more accurate and effic

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