Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
Abstract Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism Accessories remains poorly understood.Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct metabolic processes.Here, we identify succinate dehydrogenase (SDH) def